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Laboratory Medicine

Test catalogue

Nortriptyline (Amitriptyline)

Test Name

Nortriptyline (Amitriptyline)

Red Tube with thin top Specimen Type/Requirements

Container Type = 1 Red Top

Minimum Volume = 3 mL Blood

Tube must fill to at least ½ or greater of its vacuum capacity

Specimen Handling

Collection Instructions: Collect sample in red top tube. Avoid gold top (SST). Collect at steady state. To monitor therapy, draw trough specimen prior to morning dose or 10-12 h after last drug administration. Assay includes Amitriptyline and Nortriptyline. Note date and time of collection and last dose.

Laboratory Staff Instructions: Separate samples from cells as soon as possible. Repeated freezing and thawing of samples should be avoided

Rejection Criteria: Gel separator, grossly hemolyzed and icteric samples, Unlabeled or Not Sufficient Quantity samples will be rejected.

Stability: Separated from cells stable at room temperature for 5 days, refrigerated 2 weeks, frozen 6 months.

Transportation: Send to Core Lab as soon as possible

Required Documentation

Turnaround Time (TAT)

7 days (batched)

Test Utilization

Reference Value

Combined Metabolite: 0.20-0.60 µmol/L

Toxic : >1.80 µmol/L

Test Code



LCMS (Liquid Chromatography/Mass Spectrometry)

Testing Location


Other Information

Last Updated: November 07, 2019