Laboratory Medicine

Test catalogue

Nortriptyline (Amitriptyline)
Test Name Nortriptyline (Amitriptyline)
Specimen Type/Requirements Container Type = 1 Red Top Minimum Volume = 3 mL Blood Tube must fill to at least ½ or greater of its vacuum capacity
Specimen Handling Collection Instructions: Collect sample in red top tube. Avoid gold top (SST). Collect at steady state. To monitor therapy, draw trough specimen prior to morning dose or 10-12 h after last drug administration. Assay includes Amitriptyline and Nortriptyline. Note date and time of collection and last dose. Laboratory Staff Instructions: Separate samples from cells as soon as possible. Repeated freezing and thawing of samples should be avoided Rejection Criteria: Gel separator, grossly hemolyzed and icteric samples, Unlabeled or Not Sufficient Quantity samples will be rejected. Stability: Separated from cells stable at room temperature for 5 days, refrigerated 2 weeks, frozen 6 months. Transportation: Send to Core Lab as soon as possible
Required Documentation
Turnaround Time (TAT) 7 days (batched)	Test Utilization
Reference Value Combined Metabolite: 0.20-0.60 µmol/L Toxic : >1.80 µmol/L
Test Code NORT	Methodology LCMS (Liquid Chromatography/Mass Spectrometry)
Testing Location SMH-Biochemistry	Other Information Last Updated: November 07, 2019

Nortriptyline (Amitriptyline)

Test Name

Nortriptyline (Amitriptyline)

Specimen Type/Requirements

Container Type = 1 Red Top

Minimum Volume = 3 mL Blood

Tube must fill to at least ½ or greater of its vacuum capacity

Specimen Handling

Collection Instructions: Collect sample in red top tube. Avoid gold top (SST). Collect at steady state. To monitor therapy, draw trough specimen prior to morning dose or 10-12 h after last drug administration. Assay includes Amitriptyline and Nortriptyline. Note date and time of collection and last dose.

Laboratory Staff Instructions: Separate samples from cells as soon as possible. Repeated freezing and thawing of samples should be avoided

Rejection Criteria: Gel separator, grossly hemolyzed and icteric samples, Unlabeled or Not Sufficient Quantity samples will be rejected.

Stability: Separated from cells stable at room temperature for 5 days, refrigerated 2 weeks, frozen 6 months.

Transportation: Send to Core Lab as soon as possible

Required Documentation

Turnaround Time (TAT)

7 days (batched)

Test Utilization

Reference Value

Combined Metabolite: 0.20-0.60 µmol/L

Toxic : >1.80 µmol/L

Test Code

NORT

Methodology

LCMS (Liquid Chromatography/Mass Spectrometry)

Testing Location

SMH-Biochemistry

Other Information

Last Updated: November 07, 2019