New drug trial puts possible stroke treatment in the hands of paramedics

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New drug trial puts possible stroke treatment in the hands of paramedics

Toronto, March 13, 2015

Paramedics in Toronto, Vancouver, Richmond and the Region of Peel in suburban Toronto will soon administer a stroke drug, called NA-1, to eligible stroke victims as part of a new 558-patient randomized control trial.

The trial will begin in Toronto on March 16 and expand to the other cities thereafter.

NA-1 may reduce damage caused by stroke and is shown to improve brain function for patients undergoing brain surgery.

The study, known as FRONTIER, will compare outcomes when paramedics give either NA-1 or placebo to patients while transporting patients to the closest stroke centre. Once in hospital, patients will receive standard care for strokes.

Canadians who suffer a stroke and receive emergency services support from Peel Regional Paramedic Services, BC Emergency Health Services or Toronto Paramedic Services will be enrolled in the trial, if they meet eligibility criteria.

The Toronto, Vancouver and Region of Peel stroke centres participating in FRONTIER are:

Participant’s consent is required before a product is delivered in most clinical trials. However, given the immediate nature of emergency stoke care, the consent process has been deferred by Health Canada and the Research Ethics Boards at the centres participating in this trial. Participants and families will be informed and asked for consent to continue in the study once the medical emergency has stabilized.

Stroke is the most significant cause of neurological disability and death worldwide. It affects 62,000 Canadians and kills more than 11,000 annually.

The FRONTIER trial is supported by a Multi-Investigator Research Initiative grant from the Brain Canada Foundation and sponsored by NoNO Inc.

To learn more, please visit or contact the Rescu at 1-888-707-3015. Additional information on the trial is available at

About St. Michael's Hospital

St. Michael’s Hospital provides compassionate care to all who enter its doors. The hospital also provides outstanding medical education to future health care professionals in 27 academic disciplines. Critical care and trauma, heart disease, neurosurgery, diabetes, cancer care, care of the homeless and global health are among the hospital’s recognized areas of expertise. Through the Keenan Research Centre and the Li Ka Shing International Healthcare Education Centre, which make up the Li Ka Shing Knowledge Institute, research and education at St. Michael's Hospital are recognized and make an impact around the world. Founded in 1892, the hospital is fully affiliated with the University of Toronto.

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