Keenan Research Centre

Scientist Profiles

Image of Haibo Zhang

Haibo Zhang

MD (anaesthesia), Tianjin University; PhD (intensive care medicine), Free University of Brussels; Stepping Stones Teaching Certificate, University of Toronto

Affiliations

Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital

Professor, Anesthesia, University of Toronto

Professor, Medicine, University of Toronto

Professor, Physiology, University of Toronto

Faculty member, Institute of Medical Sciences, School of Graduate Studies, University of Toronto

Research Interests

Lung infection and immunity, host defense, sepsis

Selected Publications

Link to Pub Med

Research Activities

My major research interests relate to lung infection and immunity and sepsis. Specifically, my lab is working on:

  1. Human neutrophil peptides in host defense and lung injury: To examine the molecular mechanisms by which human neutrophil peptides impair phagocytic function and inflammatory responses in human cystic fibrosis and other lung diseases, and develop therapeutic approaches targeting the mechanisms of action of human neutrophil peptides.
  2. Novel LPS receptor: To identify alternative LPS receptors in lung cells and alveolar macrophages independent of TLR4.
  3. Cytokine and bacterial interaction: To examine the mechanisms by which cytokines kill and promote bacterial proliferation. My laboratory uses a number of model systems including in vitro primary human and murine cells and transformed human and murine cell lines, ex vivo lung explants and various animal models.
  4. I have been involved in clinical trials related to biomarkers of inflammation.

Other Activities

  1. Associate Editor, Intensive Care Medicine
  2. Graduate Admission Committee, Institute of Medical Science, University of Toronto
  3. Chairman, Internal Peer-review Program, the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital
  4. Animal Care and Use Committee, the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital
  5. Basic Research Committee, the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital

Educational Activities

I have appointments in the departments of Anesthesia, Medicine and Physiology at the University of Toronto. I supervise MSc and PhD students associated with the Institute of Medical Science and the Department of Physiology. I also supervise three to four post-doctoral fellows at any given time. I am interested in accepting additional fellows in the area of lung infection and immunity and ventilator-induced lung injury.

Contact

Phone: 416-864-6060 Ext. 6551
Fax: 416-864-5277
E-mail: ZhangH@smh.ca

| Share