Keenan Research Centre

Scientist Profiles

Image of Darrell H.S. Tan

Darrell H.S. Tan

BSc, McGill University; MD, University of Toronto; PhD, University of Toronto

Affiliations

Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital

Clinician Scientist, Division of Infectious Diseases, St. Michael’s Hospital

Assistant Professor, Department of Medicine, University of Toronto

Affiliate Scientist, Toronto General Research Institute

Clinical Specialty

Infectious diseases

Research Interests

HIV/AIDS, HIV and sexually transmitted co-infections, herpes simplex virus, syphilis, HIV pre- and post-exposure prophylaxis, non-AIDS comorbidities

Research Activities

My research focuses on three related themes in the area of HIV co-infections and co-morbidities: first, the relationships between HIV-1 and common co-infections such as herpes simplex virus type 2 (HSV-2) and syphilis; second, how these pathogens contribute to the chronic inflammatory state that characterizes even successfully treated HIV infection, and which in turn is thought to drive the development of the emerging non-AIDS morbidities in HIV patients; and third, the optimal management strategies for these emerging HIV comorbidities such as renal and bone disease. Current projects include an international randomized clinical trial of valacyclovir for attenuating HIV disease progression, several observational studies examining inflammatory markers in HIV and diagnostic studies in HIV/syphilis co-infection. I am also supervising trainees on various projects related to pre- and post-exposure prophylaxis for HIV.

Selected Research

Link to Pub Med

Other Activities

  1. Site Director for St Michael’s Hospital, Canadian HIV Trials Network
  2. Scientific Review Committee, Canadian HIV Trials Network
  3. Infectious Diseases Module Coordinator, Global Health Education Institute, Dalla Lana School of Public Health

Educational Activities

I am interested in supervising students at all levels on research projects related to HIV and other infectious diseases.

Contact

E-mail: TanD@smh.ca
Phone: 416-864-5568
Fax: 416-864-5310