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Keenan Research Centre

Scientist Profiles

Arthur S. Slutsky

MD, McMaster; M.A.Sc. (industrial engineering), University of Toronto; B.A.Sc. (engineering science), University of Toronto

Affiliations

Vice President of Research, St. Michael's Hospital

Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital

Division Director, Interdepartmental Division of Critical Care Medicine, University of Toronto

Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto

Research Interests

Acute lung injury, ventilator-induced lung injury, mechanical ventilation

Selected Publications

Link to Pub Med

Research Activities

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

Other Activities

1. Member, International Advisory Board, UpToDate in Pulmonary and Critical Care Medicine, American Thoracic Society
2. Co-Chair, Sub-committee of Vice Presidents of Health Research, Association of Canadian Academic Healthcare Organizations
3. Member, Institute Advisory Board, Canadian Institutes of Health Research
4. Associate Editor, Canadian Respiratory Journal
5. Editorial board member (past or present): Critical Care Medicine; Critical Care; New Horizons; Sepsis; Canadian Respiratory Journal; MD Consult Respiratory and Critical Care; Current Opinion in Critical Care; American Journal of Respiratory and Critical Care Medicine; Journal of Applied Physiology
6. Member, International Advisory Board, European Foundation for Training and Research in Anesthesia, Surgery and Intensive Care Medicine
7. Advisory Group Member, ERS High Level Scientific Congress, European Respiratory Society
8. Member, Senior Biomedical Research Service, Food and Drug Administration
9. Member, Editorial Board, MD Consult Respiratory and Critical Care Medicine Specialty Service
10. Member, Critical Care Editorial Advisory Board, Medscape
11. Member, Data and Safety Monitoring Board of the ARDS Clinical Network, National Institutes of Health-National Heart, Lung and Blood Institute
12. Member, Review Committee for Specialized Centers of Research for ARDS, National Institutes of Health, National Heart, Lung and Blood Institute
13. Member, Medical Board of Directors, The ARDS Foundation
14. Previous member of Gairdner Foundation, Medical Review Panel
15. Member, FDA Advisory committee for Respiratory and Anesthesiology Devices Panel
16. Chairman or member of a number of data safety monitoring boards

Educational Activities

I have appointments in the department of Medicine, Surgery and the Institute of Biomaterials and Biomedical Engineering. I currently supervise two postdoctoral fellows.

Contact

Phone: 416-864-5637
Fax: 416-864-5117
E-mail: SlutskyA@smh.ca