Keenan Research Centre
MD, University of Buenos Aires; National Board of Medical Examiners (neurology), University of Buenos Aires; M.Sc. (clinical effectiveness), Harvard School of Public Health and University of Buenos Aires, FRCPC
Director, Stroke Research Unit, Mobility Program, St. Michael's Hospital
Scientist in the Li Ka Shing Knowledge Institute of St. Michael's Hospital
Associate Professor, Medicine, St. Michael's Hospital, University of Toronto
Cross-appointment, Health Policy, Management and Education (HPME), University of Toronto
Adjunct Scientist, Institute of Clinical Evaluative Sciences (ICES)
Stroke outcome, health services research, pharmacoeconomic and stroke therapy, quality of care, translating new emerging therapies into clinical practice, epidemiology of cerebrovascular disease
My current research focuses are Stroke Outcomes and Health Services Research. Specifically, I have looked at the domains of stroke care delivery, prevention, and improved stroke recovery. Both my research training and publications reflect my longstanding interests in these 3 areas. Ultimately, my personal goal is to identify innovative strategies which aim to improve access of care, stroke prevention, and reduce disability in stroke survivors.
Specifically, our team have looked at the domains of stroke care delivery, prevention, and improved stroke recovery. Both my research training and publications reflect my longstanding interests in these 3 areas. The first includes the assessment of how organized inpatient care affects stroke outcomes. We have developed and validated a risk score (called iScore) and a web tool to assist clinicians estimate clinical outcomes after a stroke. The iScore also showed to predict clinical response to thrombolysis (clot-buster medication) after an acute ischemic stroke. The second includes adherence to the guidelines and risk of stroke in selected populations. The last relates to a novel area: the use of virtual reality of stroke rehabilitation. More recently, we have taken it a step further by exploring the use of virtual reality with Nintendo Wii gaming technology in patients with recent strokes. We are also in the process of comparing different virtual reality systems.
To accomplish these tasks, I formed and led a working group on stroke outcome research involving many leading stroke researchers in Canada, and other specialists interested in stroke, called SORCan (Stroke Outcomes Research Canada. This has led to a series of publications, and others being submitted or in press. Our work has been highlighted in two summary reviews on ‘Advances in Health Policy and Outcomes’ published in STROKE Journal (Rudd et al. Stroke 2009;40;e301-e304 and Williams et al. Stroke 2010;41: e77-e80) and LANCET (Lancet 2011; 377: May 14). SORCan has the potential to be expanded and make worldwide contributions. Some of my success in these areas resulted from this productive network of colleagues and researchers in the field.
Our research program includes four main areas: stroke outcome research, stroke epidemiology, stroke & health policy, and new emerging therapies in cerebrovascular disease.
Accomplishments: Since my academic appointment at St. Michael’s Hospital (and creation of the Stroke Outcomes Research Program) in July 2006, I have obtained 3 personnel award (the 2008-2011 HSFO Clinician-Scientist Award, the 2012-2017 HSFC Distinguished Clinician Scientist Award and the HSFO MacDonald Research Award), 13 peer-reviewed operating grants (8 as PI). I have over 90 peer-reviewed papers published/in-press, 9 editorials, 4 book chapters, and more than 100 abstracts.
I have now established a successful research program involving a network of researchers studying Stroke Outcomes and Health Services Research that is unique within Canada, and perhaps globally.
- Distinguished Clinician Scientist Award and Mac Donald Award, Heart and Stroke Foundation of Canada, 2012
- Member, American Academy of Neurology (AAN)
- Member, Critical care group, World Federation of Neurology (CC-WFN)
- Member, Argentinean Neurological Society (SNA)
- Founder member, Iberoamerican Society of Cerebrovascular Disease
- Member, Association of Organ Procurement for Transplantation (APProAT)
- Member, College of Physicians and Surgeons Ontario (CPSO)
- Member, Canadian Medical Protective Association (CMPA)
- Member, Canadian Stroke Network (CSN)
- Member, Canadian Stroke Consortium (CSC)
- Member, Ontario Medical Association (OMA)
- Member, International Stroke Society (ISS)
- Editorial board member, Stroke (AHA Journal)
- Reviewer, JAMA, Neurology, STROKE, Lancet, Lancet Neurology, CMAJ, Arch Int. Med., among others
I have appointments in the Department of Medicine, the Department of Health Policy, Management and Evaluation (HPME) and the Institute of Medical Science (IMS) at the University of Toronto. I supervise several postgraduate students in different areas including: stroke epidemiology, health services research, health policy, pharmacoeconomics and new therapies in cerebrovascular disease.