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Keenan Research Centre

Scientist Profiles

Dominic S. Ng

FRCPC, College of Physicians and Surgeons of Canada; MD, Medical Council of Canada; PhD, University of Toronto

Affiliations

Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital

Assistant Professor, Medicine, University of Toronto

Clinical Specialty

Endocrinology and metabolism

Research Interests

Dyslipidemia, atherosclerosis, obesity and diabetes

Selected Publications

Link to Pub Med

Research Activities

My research lab is primarily interested in the area of genetics of lipid disorders, and their roles in diabetes, adiposity and cardiovascular diseases with special emphasis on high density lipoprotein (HDL) metabolism. We use transgenic/knockout mice as models and our tools include in vivo experiments, ex vivo and in vitro assays at tissue, cellular, and molecular levels. We are particularly interested in using in vivo mouse model experiments to examine the impact of various genetic forms of dyslipidemic disorders and their interactions with other dysmetabolic states like insulin resistance, oxidative stress, atherogenesis and thrombogenesis. Detailed analyses of these animal models using cellular, molecular and genetic markers will also be carried out to elucidate the underlying mechanism of such disease processes and their interactions. Such genetic models are also used to study the effects of dietary and novel drug interventions. I also participate in a number of multi-center randomized control clinical trials in the prevention of cardiovascular diseases and in the treatment of obesity.

Other Activities

1. President, Toronto Diabetes Association, 2005-present
2. Research group co-leader (diabetes/lipid/obesity group), division of endocrinology, University of Toronto, 2002-present
3. Member, Canadian Institutes of Health Research (CIHR) cardiovascular disease external advisory panel, 2006-2011

Educational Activities

I am a member of the School of Graduate Studies, University of Toronto, and cross-appointed to the departments of Physiology and Laboratory Medicine and Pathobiology

Contact

Phone: 416-864-5197
Fax: 416-864-5584
E-mail: NgD@smh.ca