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Keenan Research Centre

Scientist Profiles

R. Loch Macdonald

MD, University of British Columbia; PhD, University of Alberta

Affiliations

Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital

Professor, Surgery/Neurosurgery, University of Toronto

Division Head, Neurosurgery, St. Michael's Hospital

Keenan Endowed Chair, Surgery, St. Michael's Hospital

Clinical Specialty

Neurosurgery

Research Interests

Subarachnoid hemorrhage, cerebral vasospasm, cerebral blood flow and metabolism, stroke, cerebral aneurysms, cerebrovascular malformations

Selected Publications

Link to Pub Med

Research Activities

My major research interests are in the field of aneurismal subarachnoid hemorrhage and cerebral vasospasm. We are investigating causes of delayed neurological deterioration after subarachnoid hemorrhage using animal models and testing hippocampal electrophysiology and function, animal behavior, learning and memory and changes in gene expression and function. We also are studying mechanisms of large artery vasospasm after aneurismal subarachnoid hemorrhage. We found that endothelin antagonists affect this disease and we use patch clamp electrophysiology, molecular biology, whole artery isometric tension studies and in vivo imaging to assess mechanisms of contraction including the role of ion channels and TRP proteins.

Other Activities

1. Steering committee and liaison between steering and critical events committees, CONSCIOUS-3: A prospective, multi-centre, double-blind, randomized, placebo-controlled, parallel-group study to assess the efficacy and safety of clazosentan in reducing vasospasm-related morbidity and all-cause mortality in adult patients with aneurysmal subarachnoid hemorrhage treated by endovascular coiling
2. Editorial board, Journal of Neurosurgery, Neurosurgery, Stroke, Neurocritical Care, Surgical Neurology
3. Adhoc reviewer, multiple medical journals

Educational Activities

I have an appointment in the Institute of Medical Science at the University of Toronto and currently supervise two trainees.

Contact

Phone: 416-864-5452
Fax: 416-864-5634
E-mail: MacdonaldLo@smh.ca