Keenan Research Centre
Scientist Profiles
Claudia dos Santos
MD, University of Toronto; M.Sc., University of Toronto; B.Sc. (Hons), Trent University
Affiliations
Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital
Assistant Professor of Medicine, Department of Medicine, University of Toronto
Clinician Scientist, Research, University of Toronto
Member, Collaborative Graduate Program in Genome Biology and Bioinformatics, University of Toronto
Clinical Specialty
Critical care medicine
Research Interests
Acute respiratory distress syndrome, ventilator-induced lung injury, mechanotransduction, organ failure, mechanical ventilation, differential gene expression
Selected Publications
Research Activities
My major research interest is acute lung injury. This can be caused by either biomolecular or biophysical insults to the lungs, such as an infection or the mechanical injury resulting from mechanical ventilation itself. My lab is dedicated to understanding the interaction between patients and the breathing machine and finding new ways to identify individuals, who are at higher risk for developing lung injury, diagnose, treat and monitor improvement from injury. To accomplish our goals, we have developed various model systems from basic epithelial cell stretch models to animal models of lung injury. We exploit whole genome approaches, such as microarray technology, to identify novel molecular targets and use various computational strategies to analyze our data. We are also interested in understanding how and why critically ill patients develop multi-organ failure. To answer some of the more complex questions my lab also collaborates actively with clinical researchers involved in state of the art clinical trials related to novel mechanical ventilation strategies.
Other Activities
- Chair of the International Affairs Committee of the American Thoracic Society
- Member of the ATS Critical Care Assembly
- Member of the research Subcommittee for the Interdepartmental Division of Critical Care
Educational Activities
I have an appointment as member of the Collaborative Graduate Program in Genome Biology and Bioinformatics.
Contact
Phone: 416-864-8575
Fax: 416-864-6013
E-mail: DossantosC@smh.ca
