Keenan Research Centre
Scientist Profiles
Andrew Advani
B.Sc. (first class), Edinburgh University, UK; MBChB (with Honours), Edinburgh University, UK; FRCP (UK), Royal College of Physicians of Edinburgh, UK; PhD, Newcastle University, UK
Affiliations
Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital
Assistant Professor, Medicine, University of Toronto
Clinical Specialty
Endocrinology and metabolism
Research Interests
Diabetic complications, nephropathy, hypertension, VEGF, endothelial dysfunction, renin angiotensin system, reactive oxygen species, epigenetics, SDF-1/CXCR4, VEGF
Research Activities
My research interests relate to the molecular pathology of diabetic complications and in particular kidney disease in diabetes. Diabetic nephropathy is the most common cause of kidney failure in Canada. My laboratory is committed to finding new treatments to slow or even reverse the progression of kidney disease. Our research is truly translational, studying the cellular processes involved in the development of the cardiovascular complications of diabetes and investigating the action of novel therapies both in vitro and in vivo. Through this, we hope to bring new treatments directly from the bench to the bedside. My research is focused on the critical role of high blood pressure in the progression of kidney disease and I am studying new ways to stimulate endothelial regeneration, the repair of the small blood vessels, damaged due to diabetes.
Educational Activities
I am an associate member of the Institute of Medical Sciences and am open to applications from graduate students and post-doctoral fellows.
Contact
Phone: 416-864-6060, Ext. 8413
Fax: 416-867-3696
E-mail: advania@smh.ca
