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Laboratory Medicine

Test catalogue

Free Metanephrine, (Metanephrine, Normetanephrine, 3-Methoxytyramine), Random Urine

Test name

Free Metanephrine, (Metanephrine, Normetanephrine, 3-Methoxytyramine), Random Urine

Urine sample Specimen Type / Requirements

Container Type = Sterile Container

Minimum Volume = 25mL Urine

Specimen Handling

Collection Instructions: Collect random urine in a sterile container. It is important that the urine is refrigerated during the collection. Restrict caffeine, nicotine and alcohol 24hrs prior to collection. Discontinue Methyldopa (Aldomet) at least 5 days prior to collection.

Laboratory Staff Instructions: Acidify aliquot with 6 mol/L (6N) HCl. The final pH of the urine must be 2.0 - 4.0 before analysis.

Stability: stable for 1 month refrigerated at 2-8°C and longer if frozen.

Transportation: Send sample to SMH core lab as soon as possible.

Sample Rejection Criteria: Unlabeled, leaky or samples of non sufficient quantity.

Required Documentation

Turnaround Time (TAT)

10 Days

Test Utilization

Reference Value

Free Metanephrine/Creatinine Ratio : < 31 nmol/mmol creatinine

3-Methoxytyramine/Creatinine Ratio : < 45.0 nmol/mmol creatinine

Test Code



liquid chromatography-mass
spectrometry (LC-MS/MS).

Testing Location


Other Information

Last Updated: April 27, 2020