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Laboratory Medicine

Test catalogue

Free Metanephrine, (Metanephrine, Normetanephrine, 3-Methoxytyramine), 24hrs Urine

Test name

Free Metanephrine, (Metanephrine, Normetanephrine, 3-Methoxytyramine), 24hrs Urine

Plain 24 bottle Specimen Type / Requirements

Container Type = 24 hour 25mL 6 mol/L (6N) HCl acid Bottle

Minimum Volume = 25mL urine from mixed urine Collection

Specimen Handling

Collection Instructions: Collect urine in a container with 25 mL 6 mol/L (6N) HCl acid. It is important that the urine is refrigerated during the collection. Restrict caffeine, nicotine and alcohol 24hrs prior to collection. Discontinue Methyldopa (Aldomet) at least 5 days prior to collection. Other drugs usually do not interfere with this assay. State 24h volume and collection date.

Write your "start" and "end" date and time of collection on the collection label or requisition.

Stability: stable for 1 month refrigerated at 2-8°C and longer if frozen.

Transportation: Send sample to SMH core lab as soon as possible.

Sample Rejection Criteria: Unlabeled or leaking specimen

Required Documentation

Turnaround Time (TAT)

10 Days

Test Utilization

Reference Value

Free Metanephrine Male: < 270 nmol/day

Free Metanephrine Female: < 170 nmol/day

Free Normetanephrine Male and Female: < 300 nmol/day

3-Methoxytyramine Male: < 380 nmol/day

3-Methoxytyramine Female: < 300 nmol/day

Test Code



liquid chromatography-mass
spectrometry (LC-MS/MS).

Testing Location


Other Information

Last Updated: April 27, 2020