Critical Care
Intensive Care Units: Andrew Baker, MD, FRCPC
Chief, Department of Critical Care; Medical Director, Trauma & Neurosurgery Program and Intensive Care Unit; Professor, Departments of Anesthesia and Surgery, University of Toronto
Medical Speciality
Anesthesia & Intensive Care
Clinical Activities
Trauma and neurosurgery intensive care
Major Interests
- Clinical monitoring and treatment of severe closed head injury and subarachnoid hemorrhage.
- Involvement of the metabotropic receptor in traumatic brain injury.
- Evolution of white matter deterioration following traumatic brain injury.
- Electrophysiology of traumatic brain injury in corpus callosum and hippocampus.
- Impact of glucose in anoxic brain injury.
- Blood and blood substitute resuscitation of brain injury.
Select Recent Publications
Park E, Bell JD, Siddiq I, Baker AJ. An analysis of regional microvascular loss and recovery following two grades of fluid percussion trauma: a role for hypoxia inducible factors in traumatic brain injury. Journal of Cerebral Blood Flow & Metabolism 2008 Dec 17. [Epub ahead of print]
Zwienenberg-Lee M, Hartmann J, Rudisill N, Madden L, Baker AJ et al. The effect of prophylactic transluminal balloon angioplasty on cerebral vasospasm and outcome in patients with Fisher Grade III subarachnoid hemorrhage. Results of a phase II multi-centre randomized clinical trial, The BPAV Study Group. Stroke 39, 1759-1765. 2008
Park E, Bell JD, Baker AJ. Traumatic brain injury: Can the consequences be stopped? Canadian Medical Association Journal, 178(9) 1163-1170 2008
Baker AJ, Park E, Hare G, Liu, Mazer, D. Effects of resuscitation fluid on neurological physiology after cerebral trauma and hemorrhage. The Journal of Trauma, Injury, Infection and Critical Care 64:2, 348-357 2008
Orser BA, Mazer CD, Baker AJ. Awareness during anesthesia. CMAJ 178:2, 185-188 2008
Rigamonti A, Ackery A, Baker AJ. Transcranial Doppler monitoring in subarachnoid hemorrhage: a critical tool in critical care. Can J Anesth. 55:2, 112-123 2008
Bell J, Ai J, Chen Y and Baker AJ. Mild in vitro trauma induces rapid GluR2 endocytosis, robustly augments calcium permeability, and enhances susceptibility to secondary excitotoxic insult in cultured Purkinje cells. Brain 130:10,2528-2542 2007 SRA
Ai J, Liu E, Wang J, Chen Y,Yu, J Baker AJ. Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. Journal of Neurotrauma 24:6, 960-978 2007
Park E, Liu E, Shek M, Baker AJ. Heavy neurofilament accumulation and alpha-spectrin degradation accompanies cerebellar white matter functional deficits following forebrain fluid percussion injury. Experimental Neurology 204: 49-57 2007
Ai J, Liu E, Park E, Baker A. Structural and functional alterations of cerebellum following fluid percussion injury in rats. Experimental Brain Research 177:95-112 2007
Hare GMT, Harrington A, Liu E, Wang JL, Baker AJ, Mazer CD. Effect of oxygen affinity and molecular weight of HBOCs on cerebral oxygenation and blood pressure in rats. Can J Anesth 53:1030-1038; 2006
Shemie SD, Baker AJ, Knoll G, et al. National recommendations for donation after cardiocirculatory death in Canada. Canadian Medical Association Journal 175:8 S1-S24 October 10 2006
Shemie S, Doig C, Dickens B, Byrne P, Wheelock B, Rocker G, Baker A, Seland tp, Guest C, Cass D, Jefferson R, Young K, Teitelbaum J, on behalf of the Pediatric Reference Group and the Neonatal Reference Group. Severe brain injury to neurological determination of death: Canadian forum recommendations. Canadian Medical Association Journal 174:6 S1-12 2006
Shemie S, Ross H, Pagliarello J, Baker A, Greig P, Brand T, Young K, Doig C. Organ donor management in Canada: recommendations of the forum on Medical Management to Optimize Donor Organ Potential. Canadian Medical Association Journal 174:6 S13-30 2006
Contact Us
Phone: 416-864-5510
Fax: 416-864-5512
E-mail: BakerA@smh.ca
