Critical Care

Intensive Care Units: Andrew Baker, MD, FRCPC

Andrew Baker Chief, Department of Critical Care; Medical Director, Trauma and Neurosurgery Program; Scientist, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital; Professor, Departments of Anesthesia and Surgery, University of Toronto

Medical Speciality

Critical Care and Anesthesia

Clinical Activities

Trauma and neurosurgery intensive care

Major Interests

  • Quality of care in Critical Care
  • Clinical monitoring and treatment of severe closed head injury and subarachnoid hemorrhage.
  • Physiology of glutamate receptors in traumatic brain injury.
  • Evolution of white matter deterioration after traumatic and blast induced brain injury.
  • Electrophysiology of traumatic brain injury in corpus callosum and hippocampus.
  • Impact of glucose in anoxic brain injury.
  • Blood and blood substitute resuscitation of brain injury.

Selected Publications

Park E, Gottlieb JJ, Cheung B, Shek PN, Baker AJ. A model of low-level primary blast brain trauma results in cytoskeletal proteolysis and chronic functional impairment in the absence of lung barotrauma. Journal of Neurotrauma. 28(3): 343-357, 2011

Morrison LJ, Baker AJ, Rhind SG, et al The Toronto prehospital resuscitation-head injury and multiorgan dysfunction trial: Feasibility study of a randomized controlled trial. Journal of Critical Care. 2010 Nov 22.

Bulger EM, May S, Brasel KJ, Schreiber M, Kerby JD, Tisherman SA, Newgard C, Slutsky A, Coimbra R, Emerson S, Minei JP, Bardarson B, Kudenchuk P, Baker A, et al;. Out-of-hospital hypertonic resuscitation following severe traumatic brain injury. A Randomized Controlled Trial. Journal of the American Medical Association. 304 (13): 1455-1464, 2010

Baker AJ . What is the role of extracorporeal membrane oxygenation for hypoxic failure during an influenza pandemic? Canadian Journal of Anaesthesia 57: 201-205, 2010

Morrison LJ, Rizoli SB, Schwartz B, Rhind SG, Simitciu M, Perreira T, Macdonald R, Trompeo A, Stuss DT, Black SE, Kiss A, Baker AJ. The Toronto prehospital hypertonic resuscitation-head injury and multi organ dysfunction trial (TOPHRHIT)-methods and data collection tools. Trials 10:105, 2009

Bell JD, Park E, Ai J, Baker AJ. PICK1-mediated GluR2 endocytosis contributes to cellular injury after neuronal trauma. Cell Death and Differentiation 16, 1665-1680. 2009

Allard CB, Scarpelini S, Rhind S, Shek P, Baker AJ, Tien H, Fernando M, Tremblay L, Morrison L, Pinto R, Rizoli S. Abnormal coagulation tests are associated with progression of traumatic intracranial hemorrhage. Journal of Trauma 67, 959-967. 2009

Baker AJ. A closer look at organ donation after cardiocirculatory death in Canada . Canadian Journal of Anaesthesia 56 (11):789. 2009

Baker AJ, Rhind SG, Morrison LJ, Black S, Crnko NT , Shek PN, Rizoli, SB. Resuscitation with hypertonic saline-dextran reduces serum biomarker levels and correlates with outcome in severe traumatic brain injury patients. Journal of Neurotrauma 26(8):1227-40. 2009

Park E, Bell JD, Siddiq I, Baker AJ. An analysis of regional microvascular loss and recovery following two grades of fluid percussion trauma: a role for hypoxia inducible factors in traumatic brain injury. Journal of Cerebral Blood Flow & Metabolism 29(3):575-84. 2009

Zwienenberg-Lee M, Hartmann J, Rudisill N, Madden L, Baker AJ et al. The effect of prophylactic transluminal balloon angioplasty on cerebral vasospasm and outcome in patients with Fisher Grade III subarachnoid hemorrhage. Results of a phase II multi-centre randomized clinical trial, The BPAV Study Group. Stroke 39, 1759-1765. 2008

Park E, Bell JD, Baker AJ. Traumatic brain injury: Can the consequences be stopped? Canadian Medical Association Journal 178(9) 1163-1170 2008

Baker AJ, Park E, Hare G, Liu, Mazer, D. Effects of resuscitation fluid on neurological physiology after cerebral trauma and hemorrhage. The Journal of Trauma, Injury, Infection and Critical Care 64:2, 348-357 2008

Orser BA, Mazer CD, Baker AJ. Awareness during anesthesia. CMAJ 178:2, 185-188 2008

Rigamonti A, Ackery A, Baker AJ. Transcranial Doppler monitoring in subarachnoid hemorrhage: a critical tool in critical care. Can J Anesth. 55:2, 112-123 2008

Hare GM, Mazer CD,Hutchison JS, McLaren AT, Liu E, Rassouli A, Ai J, Shaye RE, Lockwood JA, Hawkins CE, Sikich N, To K, Baker AJ. Severe Hemodilutional Anemia Increases Cerebral Tissue Injury following Acute Neurotrauma. J Appl Physiol. 103:1021-1029 2007

Bell J, Ai J, Chen Y and Baker AJ. Mild in vitro trauma induces rapid GluR2 endocytosis, robustly augments calcium permeability, and enhances susceptibility to secondary excitotoxic insult in cultured Purkinje cells. Brain 130:10,2528-2542 2007

Ai J, Liu E, Wang J, Chen Y,Yu, J Baker AJ. Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. Journal of Neurotrauma 24:6, 960-978 2007

Park E, Liu E, Shek M, Baker AJ. Heavy neurofilament accumulation and alpha-spectrin degradation accompanies cerebellar white matter functional deficits following forebrain fluid percussion injury. Experimental Neurology 204: 49-57 2007

Ai J, Liu E, Park E, Baker A. Structural and functional alterations of cerebellum following fluid percussion injury in rats. Experimental Brain Research 177:95-112 2007

Shemie SD , Baker AJ, Knoll G, et al. National recommendations for donation after cardiocirculatory death in Canada . Canadian Medical Association Journal 175:8 S1-S24 October 10 2006

Baker AJ, Beed S, Fenwick J, Kjerulf M, Bell H, Logie S, Shepherd J. Number of deaths by neurologic criteria, and organ and tissue donation rates at three critical care centers in Canada Canadian Journal of Anesthesia 53:7 772-726 2006

Ai J, Baker AJ. Long-term potentiation of evoked presynaptic response at CA3-CA1 synapses by transient oxygen-glucose deprivation in rat brain slices. Experimental Brain Research 169:1 126-129 2006

Park E, McKnight S, Ai J, Baker AJ. Prukinje cell vulnerability to mild and severe forebrain head trauma. Journal of Neuropathology and Experimental Neurology 65:3 226-234 2006

Shemie S, Doig C, Dickens B, Byrne P, Wheelock B, Rocker G, Baker A, Seland tp, Guest C, Cass D, Jefferson R, Young K, Teitelbaum J, on behalf of the Pediatric Reference Group and the Neonatal Reference Group. Severe brain injury to neurological determination of death: Canadian forum recommendations. Canadian Medical Association Journal 174:6 S1-12 2006

Shemie S, Ross H, Pagliarello J, Baker A, Greig P, Brand T, Young K, Doig C. Organ donor management in Canada: recommendations of the forum on Medical Management to Optimize Donor Organ Potential. Canadian Medical Association Journal 174:6 S13-30 2006

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