Neuroscience Research Program

Zebrafish Neuroscience Collaborative (ZNC)

About

Zebrafish brain vessel 3D
Zebrafish brain vessel 3D

 
SMH Automated Zebrafish HTS Platform
SMH Automated Zebrafish
HTS Platform

St. Michael’s Hospital is home to the first automated high-throughput zebrafish screening facility in Canada. Zebrafish are undergoing a technological revolution in genome editing for functional genomic studies, mutagenesis to develop disease models, and high throughput screens in drug discovery. In neuroscience, massive research efforts in developing new drugs and therapies for the two most prevalent neurodegenerative diseases, Alzheimer’s and Parkinson’s, have yet to produce a cure. Novel research strategies are urgently needed to expand the knowledge of brain disease mechanisms and accelerate drug discovery.

Supported by the well-equipped St. Michael’s Hospital Zebrafish Core, the Zebrafish Neuroscience Collaborative (ZNC) synergizes our efforts to produce high impact research and discoveries. This common research goal has brought together both local and international scientists in a collaborative effort to develop a wide spectrum of zebrafish neural models to study disease mechanisms and repurpose existing drugs. The research areas include Alzheimer’s disease, Parkinson’s disease, amyotropic lateral sclerosis, epilepsy, stroke, traumatic brain injury, retinal degeneration and neural regeneration.

Core Members

Xiao-Yan Wen
Xiao-Yan Wen
Chair, ZNC
Director, Zebrafish Centre for
Advanced Drug Discovery
Tom Schweizer
Tom Schweizer
Director
Neuroscience Research Program
St. Michael's Hospital
Jonathan Brotchie
Jonathan Brotchie
Senior Scientist
Neuroscience Division
Toronto Western Research Institute
R. Loch Macdonald
Loch MacDonald
Division Head
Neurosurgery
St. Michael's Hospital
Janice Robertson
Janice Robertson
Associate Professor
Lab Medicine and Pathobiology
University of Toronto
Vince Tropepe
Vince Tropepe
Associate Professor
Cell & Systems Biology
University of Toronto
Georg Zoidl
Georg Zoidl
Professor
Department of Psychology
York University
Andrew Baker
Andrew Baker
Director
Brain Injury Laboratory
St. Michael's Hospital
Pierre Drapeau
Pierre Drapeau
Department Chair
Pathologie & Biologie Cellulaire
Universite de Montreal

Collaborative Network

Zebrafish Collaborative Network Map