Neuroscience Research Program
Yeni H. Yucel
FRCPC, Royal College of Physicians and Surgeons of Canada; M.Sc. (neuroscience), University Louis Pasteur, France; PhD (neuroscience), University Louis Pasteur, France; MD, University Louis Pasteur, France
Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital
Director, Ophthalamic Pathology Laboratory, Ophthalmology and Vision Sciences, University of Toronto
Research InterestsNeuroprotection, Eye, Neurodegeneration, Diabetes, Experimental Model, In Vivo Imaging, Lymphatic Drainage from the Eye and Brain, Imaging, Human Eye Biobank
Phone: 416-864-6060 Ext. 77594
Yucel, Y. H., Johnston, M. G., Ly, T., Patel, M., Drake, B., Gumuş, E., Fraenkl, S. A., Moore, S., Tobbia, D., Armstrong, D., Horvath, E., & Gupta, N. (2009). Identification of lymphatics in the ciliary body of the human eye: a novel “uveolymphatic” outflow pathway. Experimental eye research,89(5), 810-819.
Tam, A. L. C., Gupta, N., Zhang, Z., & Yucel, Y. H. (2011). Quantum dots trace lymphatic drainage from the mouse eye. Nanotechnology, 22(42), 425101.
Ly, T., Gupta, N., Weinreb, R. N., Kaufman, P. L., & Yucel, Y. H. (2011). Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma. Vision research, 51(2), 243-250.
Gupta, N., Greenberg, G., de Tilly, L. N., Gray, B., Polemidiotis, M., & Yucel, Y. H. (2009). Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging. British Journal of Ophthalmology,93(1), 56-60.
Yucel, Y. H., Gupta, N., Zhang, Q., Mizisin, A. P., Kalichman, M. W., & Weinreb, R. N. (2006). Memantine protects neurons from shrinkage in the lateral geniculate nucleus in experimental glaucoma. Archives of ophthalmology, 124(2), 217.
Yucel, Y. H., Zhang, Q., Weinreb, R. N., Kaufman, P. L., & Gupta, N. (2001). Atrophy of relay neurons in magno-and parvocellular layers in the lateral geniculate nucleus in experimental glaucoma. Investigative ophthalmology & visual science, 42(13), 3216-3222.
My major research interests relate to retina and optic nerve as a model to study neurodegenerative diseases such as glaucoma, age-related macular degeneration and Alzheimer disease. We study the mechanisms underlying these pathologic conditions to develop new strategies to protect and regenerate neurons.
These research activities are integrated within a translational research program to improve the diagnosis and management of patients with various types of neural injury.
We are investigating also the role of the lymphatics in drainage of fluid and proteins from the eye and brain, in health and disease.
None at this time