Neuroscience Research Program

Image of Jane Topolovec-Vranic

Jane Topolovec-Vranic

PhD (Anatomy and Cell Biology), University of Western Ontario; BSc (Biology), University of Waterloo


Associate Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital

Clinical Researcher, Trauma and Neurosurgery Program, St. Michael’s Hospital

Assistant Professor, Occupational Science and Occupational Therapy, University of Toronto

Research Interests

Traumatic brain injury; Mental health; Pain Assessment; Biomarkers; Technology

Contact Information

Phone: 416-864-6060 Ext. 3421
Fax: 416-864-5629

Ennis, N., Rosenbloom, B., Canzian, S., & Topolovec-Vranic, J. (2013). Depression and anxiety in parent versus spouse caregivers of patients with traumatic brain injury: A systematic review. Neuropsychological Rehabilitation, 23(1), 1-18.

Topolovec-Vranic, J., Ennis, N., Colantonio, A., Cusimano, M.D., Hwang, S.W., Kontos, P., Ouchterlony, D., & Stergiopoulos, V. (2012). Traumatic brain injury among people who are homeless: A systematic review. BMC Public Health, 12(1), 1059.

Topolovec-Vranic, J., Pollmann-Mudryj, M.A., Ouchterlony, D., Klein, D., Spence, J., Romaschin, A., Rhind, S., Tien, H.C., & Baker, A.J. (2011). The value of serum biomarkers in prediction models of outcome after mild traumatic brain injury. The Journal of Trauma and Acute Care Surgery, 71(5), S478-S486.

Topolovec-Vranic, J., Canzian, S., Innis, J., Pollmann-Mudryj, M. A., McFarlan, A. W., & Baker, A. J. (2010). Patient satisfaction and documentation of pain assessments and management after implementing the adult nonverbal pain scale. American Journal of Critical Care, 19(4), 345-354.

Topolovec-Vranic, J., Cullen, N., Michalak, A., Ouchterlony, D., Bhalerao, S., Masanic, C., & Cusimano, M. D. (2010). Evaluation of an online cognitive behavioural therapy program by patients with traumatic brain injury and depression. Brain Injury, 24(5), 762-772.

My research program is aimed at improving outcomes for patients following traumatic brain injury (TBI). For the acute phase of injury my research examines ways to better assess pain in non-verbal, critically ill patients. I am currently the co-PI of a CIHR grant (2012-2015) aimed at revising the Critical Care Pain Observation Tool specifically for patients who have sustained injury to the brain.

In the post-acute phase of injury my research focuses on improving post-concussive symptoms such as depression, headache, and dizziness. I am developing a technology-based self-help approach for the treatment of depression in patients with mild or moderate TBI.

Additional research interests include examining the prevalence and implications of TBI for individuals who are homeless, using biomarkers to diagnose and prognosticate outcomes following TBI, and understanding the informed consent process for research in vulnerable populations such as the critically ill.

None at this time