Neuroscience Research Program

Image of Gustavo Saposnik

Gustavo Saposnik

MD, University of Buenos Aires; National Board of Medical Examiners (neurology), University of Buenos Aires; M.Sc. (clinical effectiveness), Harvard School of Public Health and University of Buenos Aires, FRCPC


Director, Stroke Research Unit, Mobility Program, St. Michael's Hospital

Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital

Staff physician, Division of Neurology, St. Michael's Hospital

Associate Professor in Medicine, Division of Neurology, Department of Medicine, University of Toronto

Director, Center for Virtual Reality studies (CVR), Division of Neurology, Li Ka Shing Knowledge Institute, St Michael’s Hospital

Associate Member, Faculty of Medicine, Heart and Stroke Foundation Centre for Stroke Recovery

Chair, Stroke Outcome Research Canada (SORCan) Working Group

Director, Stroke research Unit, Division of Neurology, Department of Medicine, University of Toronto

Co-Director, Stroke Program, St. Michael’s Hospital

Research Interests

Stroke, Virtual Reality, Imaging, Outcomes Research, Clinical Trials, Decision Making, Guidelines

Contact Information

Phone: 416-864-5155
Fax: 416-864-5150

Saposnik, G., Guzik, A. K., Reeves, M., Ovbiagele, B., & Johnston, S. C. (2013). Stroke Prognostication using Age and NIH Stroke Scale SPAN-100.Neurology, 80(1), 21-28.

Saposnik, G., Fang, J., Kapral, M. K., Tu, J. V., Mamdani, M., Austin, P., & Johnston, S. C. (2012). The iScore predicts effectiveness of thrombolytic therapy for acute ischemic stroke. Stroke, 43(5), 1315-1322.

Saposnik, G., Kapral, M. K., Liu, Y., Hall, R., O’Donnell, M., & Raptis, S. (2011). Investigators of the Registry of the Canadian Stroke Network; Stroke Outcomes Research Canada (SORCan) Working Group. IScore: a risk score to predict death early after hospitalization for an acute ischemic stroke.Circulation, 123(7), 739-749.

Saposnik, G., Barinagarrementeria, F., Brown, R. D., Bushnell, C. D., Cucchiara, B., Cushman, M., deVeber, G., Ferro, J. M., & Tsai, F. Y. (2011). Diagnosis and Management of Cerebral Venous Thrombosis A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke, 42(4), 1158-1192.

Saposnik, G., Teasell, R., Mamdani, M., Hall, J., McIlroy, W., Cheung, D., Thorpe, K. E., Cohen, L. G., & Bayley, M. (2010). Effectiveness of Virtual Reality Using Wii Gaming Technology in Stroke Rehabilitation A Pilot Randomized Clinical Trial and Proof of Principle. Stroke, 41(7), 1477-1484.

JURaSSiC: Accuracy of Clinician vs. Risk Score Prediction of Ischemic Stroke Outcomes.
The Clinician Judgment vs. Risk Score to predict Stroke outComes (JURaSSiC) study randomized 111 Clinicians with expertise in acute stroke care to predict clinical outcomes of 5 assigned case-based ischemic stroke scenarios. Participants were enrolled in the study if they were practicing clinicians who provided stroke care in Ontario and were directly involved in medical decision making during the initial presentation or hospitalization. To reflect actual clinical practice, ischemic stroke cases for scenario development were selected to be representative of the 10 most common clinical presentations (n=1,415). This was possible by creating a patient profile matrix matched by age, sex, stroke severity, stroke subtype, the presence of vascular risk factors, glucose on admission, pre-admission status and risk stratum.

Effectiveness of Virtual Reality Technology using Wii gaming system in Stroke rehabilitation: a multicentre randomized clinical study.

iPad tablet technology for HOME Rehabilitation in patients after stroke.

Stroke in the young

iScore: A risk score to predict clinical outcomes after an acute stroke - its application to different populations (

Volunteer students are being considered for a variety of projects