Neuroscience Research Program
Andrew J. Baker
MD, University of Toronto; FRCPC, University of Toronto
Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital
Professor, Departments of Anesthesia and Surgery, University of Toronto
Full Member, Institute of Medical Science, University of Toronto
Research InterestsTraumatic Brain Injury, Blast-Induced Brain Injury; White Matter Injury; Endothelial Precursor Cells; Remote Ischemic Preconditioning; Subarachnoid Hemorrhage; Neurocritical Care;
Park, E., Eisen, R., Kinio, A., & Baker, A. J. (2012). Electrophysiological white matter dysfunction and association with neurobehavioural deficits following low-level primary blast trauma. Neurobiology of disease.
Topolovec-Vranic, J., Pollmann-Mudryj, M. A., Ouchterlony, D., Klein, D., Spence, J., Romaschin, A., Rhind S., Tien HC., & Baker, A. J. (2011). The value of serum biomarkers in prediction models of outcome after mild traumatic brain injury.The Journal of Trauma and Acute Care Surgery, 71(5), S478-S486.
Morrison, L. J., Rizoli, S. B., Schwartz, B., Rhind, S. G., Simitciu, M., Perreira, T., Macdonald R., Trompeo A., Stuss DT., Black SE., Kiss A., & Baker, A. J. (2009). The Toronto prehospital hypertonic resuscitation-head injury and multi organ dysfunction trial (TOPHR HIT)-Methods and data collection tools. Trials, 10(1), 105.
Bell, J. D., Park, E., Ai, J., & Baker, A. J. (2009). PICK1-mediated GluR2 endocytosis contributes to cellular injury after neuronal trauma. Cell Death & Differentiation, 16(12), 1665-1680.
Baker, A. J., Rhind, S. G., Morrison, L. J., Black, S., Crnko, N. T., Shek, P. N., & Rizoli, S. B. (2009). Resuscitation with hypertonic saline–dextran reduces serum biomarker levels and correlates with outcome in severe traumatic brain injury patients. Journal of neurotrauma, 26(8), 1227-1240.
The Brain Injury Laboratory within the Keenan Research Centre investigates:
1. Mechanisms of white matter injury following traumatic brain injury
2. Receptor trafficking in hypoxic and traumatic brain injury
3. Application of endothelial progenitor cells in neuroprotection and recovery
4. Mechanisms of blast-induced brain injury
5. Remote ischemic preconditioning applications in brain injury
We take undergraduate summer students; we occasionally have openings for masters and doctoral graduate students within the Institute of Medical Science, University of Toronto