Neuroscience Research Program


Theme Lead - Andrew J. Baker

Neurotrauma research at St. Michael’s includes advancing the science and implementation of strategies that address the prevention and reduction of the biological deficit arising from trauma, and the resilience, recovery and rehabilitation after injury. Injury prevention research is a highlight of this centre with national leadership in several strategies, which include innovative educational and youth-oriented projects. We conduct both clinical and laboratory supported research projects aimed at reducing the biological consequences of neurotrauma. Laboratory models range from cultured cells to whole animal work, and include electrophysiology, histopathology, biochemistry and behavior methodologies. Recovery, resilience and rehabilitation research involves both laboratory supported models and innovative clinical projects such as technology-based approaches to the treatment of mental illness following traumatic brain injury.

Areas of research St. Michael’s neurotrauma scientists are investigating include:

  • Controlled blast injury model evaluating attendant brain white matter injury.
  • Impact of glucose in anoxic brain injury.
  • Blood and blood substitute resuscitation of brain injury.
  • Physiology of glutamate receptors in traumatic brain injury.
  • Biomarkers for prognosis of outcomes following severe and mild traumatic brain injury.
  • Clinical monitoring and treatment of severe closed head injury.
  • Technology-based approaches for the treatment of depression following mild traumatic brain injury.
  • Suicide and traumatic brain injury.
  • Social causes and social, cognitive and behavioural effects of traumatic brain injury, and links between traumatic brain injury and violence.
  • Awareness of the risk factors for traumatic brain injury and violence in vulnerable populations.
  • Homelessness and traumatic brain injury.
  • Injury prevention programs.
  • Pain assessment and management practices for critically injured patients.