The Subarachnoid Hemorrhage International Trialists (SAHIT)

R. Loch Macdonald
Loch MacDonald
Director
Subarachnoid Hemorrhage International Trialists Collboration

The SAHIT (Subarachnoid Hemorrhage International Trialists) Repository is a combined database of many of the most recent clinical trials that have been conducted in subarachnoid hemorrhage. The aim of this database is to provide a pooled resource from which more representative analyses could be performed that researchers around the world use to plan future clinical trials. This pooled resource will guide clinical trials in subarachnoid hemorrhage as well as aid in the development of prognostic models of subarachnoid hemorrhage. This repository currently contains data on 14,000+ SAH patients from sites all over North America, Europe, Asia, and Australia. This project includes individuals from an abundance of backgrounds participating including; St. Michael's Hospital, University of Toronto (Canada); Heinrich Heine University (Germany); University of Iowa, Columbia University, University of Pennsylvania (United States of America); Oxford University, The General Infirmary, King's College London (United Kingdom); Medical Center Utrecht (The Netherlands); Chinese University of Hong Kong (People's Republic of China).

List of Collaborators

        Clinical Trails Data

Data

No. of Patient

Courtesy of/ Facilitator/ Principal Investigator

IHAST: Intraoperative hypothermia for aneurysm surgery trial

1001

Michael Todd

ALISAH: Albumin in Subarachnoid Hemorrhage trial

47

Jose Suarez

MAPS: Matrix and platinum science trials

228

Clay S. Johnston

ISAT: International subarachnoid aneurysm trial

2143

Andrew Molyneux

HHU: Concomitant Intraventricular Fibrinolysis and Low-Frequency Rotation After Severe Subarachnoid Hemorrhage Trial of Heinrick Heine University, Germany

60

Nima Etminan and Daniel Hanggi

BRANT: British Nimodipine trial

554

Gordon Murray and John Pickard

Tirilazad trials

3552

R. Loch Macdonald

CONSCIOUS-1 trial

413

R. Loch Macdonald

MASH: Magnesium sulfate in aneurysmal subarachnoid hemorrhage trial

1484

Walter M. van den Bergh

EPO/Statin: Systemic erythropoietin/ Pravastatin therapy in SAH trial

160

Ming-Yuan Tseng and Peter J. Kirkpatrick

IMASH: Intravenous magnesium sulphate for aneurysmal subarachnoid

327

George Wong

          Institutional Data

Data

No. of Patient

Courtesy of/ Facilitator/ Principal Investigator

CARAT:cerebral aneurysm rerupture after
treatment

1010

Clay S. Johnston

Utretch: University Medical Center Utrecht, The Netherlands

433

Mervyn Vergouwen, Gabriel Rinkel

SMH: St. Michael's Hospital, Toronto

173

R. Loch Macdonald

Leeds: University of Leeds Neurocognitive observation

117

Audrey Quinn

Durham: Observational neurocognitive study from University of Durham

105

Adam Noble, Thomas Schenk

D-SAT: Database of Subarachnoid treatment of the University of Washington

439

Peter Le Roux

Chicago: SAH registry of the University of Chicago

75

R. Loch Macdonald

SHOP:  Subarachnoid hemorrhage
outcomes project of Columbia University

1500

Stephan Mayer

Published Papers

2015

Jaja BN, Lingsma H, Schweizer TA, Thorpe KE, Steyerberg EW, Macdonald RL;  on behalf of the SAHIT collaboration.Prognostic value of premorbid hypertension and neurological status in aneurysmal subarachnoid hemorrhage: pooled analyses of individual patient data in the SAHIT repository. J Neurosurg. 2015 Jan 2:1-9. Link to Pub Med

2014

Jaja BN, Attalla D, Macdonald RL, Schweizer TA, Cusimano MD, Etminan N, Hanggi D, Hasan D, Johnston SC, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Noble A, Quinn A, Schenk T, Spears J, Singh J, Todd M, Torner J, Tseng M, van den Bergh W, Vergouwen MD, Wong GK.The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage. Neurocrit Care. 2014 Dec;21(3):551-9. doi: 10.1007/s12028-014-9990-y. Link to Pub Med

2013

Macdonald RL, Jaja B, Cusimano MD, Etminan N, Hanggi D, Hasan D, Ilodigwe D, Lantigua H, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Quinn A, Schweizer TA, Schenk T, Spears J, Todd M, Torner J, Vergouwen MD, Wong GK, Singh J; SAHIT Collaboration. SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials. Transl Stroke Res. 2013 Jun;4(3):286-96. doi: 10.1007/s12975-012-0242-1. Epub 2013 Jan 7. Link to Pub Med

Macdonald RL, Cusimano MD, Etminan N, Hanggi D, Hasan D, Ilodigwe D, Jaja B, Lantigua H, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Quinn A, Schweizer TA, Schenk T, Spears J, Todd M, Torner J, Vergouwen MD, Wong GK; SAHIT Collaboration. Subarachnoid Hemorrhage International Trialists data repository (SAHIT). World Neurosurg. 2013 Mar-Apr;79(3-4):418-22. doi: 10.1016/j.wneu.2013.01.006. Epub 2013 Jan 4. Link to Pub Med

Jaja BN, Cusimano MD, Etminan N, Hanggi D, Hasan D, Ilodigwe D, Lantigua H, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Quinn A, Schweizer TA, Schenk T, Spears J, Todd M, Torner J, Vergouwen MD, Wong GK, Singh J, Macdonald RL. Clinical prediction models for aneurysmal subarachnoid hemorrhage: a systematic review. Neurocrit Care. 2013 Feb;18(1):143-53. doi: 10.1007/s12028-012-9792-z. Link to Pub Med

Current Projects

SAHIT Member Login
To access this area you must be a SAHIT member. Email sahit@smh.ca for more information.

For more information about the SAHIT Collaboration or if you wish to submit your data to be part of SAHIT please email sahit@smh.ca